Endocrine Abstracts

Background: Adipose tissue dysfunction occurring in obesity leads to a low grade chronic inflammatory state. Fat tissue from obese individuals has a high infiltration rate of macrophages contributing to the development of obesity-related inflammation. At the cellular level, inflammation can be triggered by the activation (phosphorylation) of NF-κB as well as JNK. On the other hand, palmitic acid (PA) is a saturated fatty acid found elevated in plasma from obese subjects a...

Background: Obesity is strongly associated with a state of chronic low grade systemic inflammation and insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of the metabolic phosphatidylinositol-3-kinase (PI3K)/Akt pathway of insulin. On the other hand, inflammatory response may be activated by NF-κB. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin and infl...